Table 2—

Glucose, insulin, and glucagon AUC0–9 h/9 in all subjects

AUC0–9 h/9 h
AUC9–10 h/1 h (IVGTT subjects)
AUC9–11 h/2 h (IVGTT subjects)
Kg (%/min)
Glucose (mmol/l)Insulin (mU/l)Glucagon (pg/ml)Glucose (mmol/l)Insulin (mU/l)Glucagon (pg/ml)Glucose (mmol/l)Insulin (mU/l)Glucagon (pg/ml)
Placebo*4.50 ± 0.328.67 ± 4.5372.1 ± 12.48.90 ± 1.4017.5 ± 8.2355.9 ± 11.87.34 ± 1.0513.4 ± 4.757.7 ± 11.91.00 ± 0.92
1.25 μg/kg4.78 ± 0.277.25 ± 3.6175.4 ± 10.49.53 ± 0.8219.8 ± 0.3262.3 ± 0.388.76 ± 0.6716.2 ± 0.5163.4 ± 0.571.05 ± 0.085
2.5 μg/kg4.42 ± 0.235.00 ± 1.7869.9 ± 8.829.23 ± 0.9443.0 ± 0.7750.1 ± 1.757.18 ± 0.8831.7 ± 4.3955.0 ± 1.131.98 ± 1.11
5.0 μg/kg4.54 ± 0.257.27 ± 2.1178.5 ± 17.010.053.874.87.9438.181.41.24
10.0 μg/kg4.42 ± 0.297.74 ± 3.7981.0 ± 9.1810.5 ± 0.4254.0 ± 19.459.6 ± 1.187.81 ± 0.07135.7 ± 13.062.3 ± 4.171.58 ± 0.23
12.5 μg/kg4.27 ± 0.337.71 ± 2.5287.8 ± 16.07.89 ± 0.8854.8 ± 15.468.7 ± 14.06.05 ± 0.4030.5 ± 8.1677.9 ± 7.422.39 ± 0.14
15.0 μg/kg4.16 ± 0.377.47 ± 3.6870.8 ± 16.28.83 ± 2.7935.4 ± 8.2246.4 ± 5.46.30 ± 1.6020.5 ± 2.0049.7 ± 6.582.66 ± 1.03
17.5 μg/kg4.22 ± 0.3212.1 ± 2.0182.2 ± 13.9NANANANANANANA
20.0 μg/kg4.25 ± 0.216.32 ± 1.8575.7 ± 18.18.14 ± 1.2178.1 ± 14.260.9 ± 24.46.03 ± 1.0043.3 ± 6.1667.3 ± 29.82.75 ± 0.71
  • Data are means ± SD (n = 6 unless otherwise indicated). For subjects receiving the IVGTT, the AUC9–10 h/1 h, AUC9–11 h/2 h, and Kg are shown (n = 2 unless otherwise indicated).

  • *

    * n = 15 for the AUC0–9 h/9 h, and n = 7 for the remaining parameters (AUC9–11 h/2 h, AUC9–10 h/1 h, and Kg).

  • n = 4 for the AUC0–9 h/9 h, and n = 1 for the remaining parameters (AUC9–11 h/2 h, AUC9–10 h/1 h, and Kg).