Table 4—

Meta-analysis

Study (reference no.)Difference in wound healing proportion95% CITreatment group % healingControl group % healing
Dermagraft (13)0.0678−0.054423 to 0.1901440.3850.317
Apligraf (16)0.18750.054011 to 0.3209890.5630.375
Regranex (17)0.0809−0.021649 to 0.1836380.4270.346
Hyalograft3D (plantar)0.0454−0.256722 to 0.3476310.5450.500
Hyalograft3D (dorsal)0.35410.050469 to 0.6578650.6670.313
Pooled WD (29)0.1164*0.043244 to 0.189687
  • * Estimate of between-study variance (τ2 = 0.0011) − test of difference in wound healing (WD) = 0 (z = 3.12, P = 0.002).