Meta-analysis
| Study (reference no.) | Difference in wound healing proportion | 95% CI | Treatment group % healing | Control group % healing |
|---|---|---|---|---|
| Dermagraft (13) | 0.0678 | −0.054423 to 0.190144 | 0.385 | 0.317 |
| Apligraf (16) | 0.1875 | 0.054011 to 0.320989 | 0.563 | 0.375 |
| Regranex (17) | 0.0809 | −0.021649 to 0.183638 | 0.427 | 0.346 |
| Hyalograft3D (plantar) | 0.0454 | −0.256722 to 0.347631 | 0.545 | 0.500 |
| Hyalograft3D (dorsal) | 0.3541 | 0.050469 to 0.657865 | 0.667 | 0.313 |
| Pooled WD (29) | 0.1164* | 0.043244 to 0.189687 |
↵* Estimate of between-study variance (τ2 = 0.0011) − test of difference in wound healing (WD) = 0 (z = 3.12, P = 0.002).