Table 1—

Model indexes of β-cell function as calculated from data obtained after ingestion of a breakfast (450 kcal) in eight human subjects in the presence of an intravenous infusion of saline or GLP-1

ParameterSalineGLP-1P
Insulin secretion at time 0 (pmol · min−1 · m–2)108 ± 15135 ± 20NS
Total insulin secretion (nmol · m−2)21.0 ± 1.629.7 ± 4.20.048
Insulin secretion at 7 mmol/l glucose (pmol · min−1 · m–2)103 ± 21249 ± 600.036
Slope of the dose response (pmol · min−1 · m−2 · mmol−1 · l–1)38 ± 1670 ± 260.037
Ratio of potentiation factor at time 60 min versus at time 00.97 ± 0.172.71 ± 0.420.005
Parameter of the derivative component (pmol · m−2 · mmol−1 · l–1)423 ± 127187 ± 66NS
  • Data are means ± SE. P indicates probability level of random difference between the two tests.