Table 3

Association between hs-CRP and major depression stratified by BMI or HbA1c level*

hs-CRP quintiles (interquartile range), mg/dLP for interaction
1 (0.01–0.01)2 (0.05–0.06)3 (0.07–0.09)4 (0.12–0.18)5 (0.31–0.80)
BMI <25 kg/m20.148
 Number of subjects862263324362352
 Number with major depression23710812
 OR (95% CI) for depression (model 3)0.96 (0.45–2.07)0.78 (0.28–2.21)1.00 (Ref.)0.63 (0.24–1.64)0.81 (0.32–2.01)
BMI ≥25 kg/m2
 Number of subjects291180260357322
 Number with major depression10761824
 OR (95% CI) for depression (model 3)1.67 (0.59–4.69)1.95 (0.63–5.98)1.00 (Ref.)2.09 (0.81–5.39)2.69 (1.09–7.08)
HbA1c <7.5% (58 mmol/mol)
 Number of subjects8292613474063810.309
 Number with major depression207111014
 OR (95% CI) for depression (model 3)0.83 (0.39–1.77)0.90 (0.34–2.40)1.00 (Ref.)0.70 (0.29–1.69)1.10 (0.49–2.51)
HbA1c ≥7.5% (58 mmol/mol)
 Number of subjects324182237313293
 Number with major depression13651620
 OR (95% CI) for depression (model 3)1.94 (0.67–5.61)1.58 (0.47–5.39)1.00 (Ref.)2.01 (0.71–5.69)2.27 (0.81–6.36)
  • Model 3 adjusted for age, sex, smoking, type of diabetes therapy, diabetic nephropathy, arthritis, nonsteroidal anti-inflammatory drug use, and exercise (low, middle, and high) (21).