Table 2—

Change from baseline after 3 months of treatment

MetforminPlaceboP
n1413
Δ SI (× 10−4 min−1 · μU−1 · ml−1)2.6 (CI 1.0–4.1)2.5 (CI 1.9–2.9)0.26
Δ HbA1c (%)–0.3 ± 0.70.3 ± 0.7*0.03
Δ fasting glucose (mmol/l)–0.9 ± 3.8–0.5 ± 3.2*0.04
Δ insulin dose (units · kg−1 · day−1)–0.14 ± 0.10.02 ± 0.2*0.01
Δ BMI (kg/m2)–0.05 ± 1.00.2 ± 0.50.35
  • Data are means ± SD, except for SI, which is expressed as geometric mean and 95% CI.

  • *

    * P < 0.05 vs. metformin group.