Table 2—

Summative statements as AUC over the study period of pre- and postmenopausal women with and without diabetes

Women without diabetes
Women with diabetes
Significant difference ± diabetes
PremenopausalPostmenopausalPremenopausalPostmenopausalPremenopausalPostmenopausal
n8888
Glucose AUC (mmol/l per 6 h)78.9 (67.5–230.1)73.7 (65.4–249.6)166.8 (100.4–219.0)118.4 (57.7–236.4)NSNS
Insulin AUC (pmol/l per 6 h)600.7 (438.7–968.9)541.8 (148.3–1,199.1)479.6 (170.1–1,749.3)509.7 (240.4–728.0)NSNS
Triglycerides AUC (mmol/l per 6 h)7.0 (4.3–14.6)*12.4 (4.7–18.5)21.1 (15.5–41.8)18.4 (11.5–40.8)0.010.05
13C-PA in triglycerides AUC (ng/ml per 6 h)25.2 (12.1–49.4)48.5 (15.5–77.2)53.8 (27.7–172.0)47.8 (24.6–121.6)0.01NS
NEFA AUC (mmol/l per 6 h)462.9 (368.6–699.3)372.0 (282.2–555.2)569.7 (424.9–791.5)670.2 (550.0–1,252.4)0.050.01
13C-PA in NEFA AUC (ng/ml per 6 h)2.2 (1.8–2.9)2.1 (1.2–5.2)1.7 (1.5–5.8)2.2 (1.4–6.5)NSNS
Breath 13CO2 AUC (% of administered dose per 24 h)22.5 (18.0–31.5)17.2 (11.2–23.02)24.1 (15.4–29.1)22.5 (19.1–34.9)NS0.01
  • Values shown are median (range). Superscript denotes significantly different from postmenopausal women within corresponding group by Kruskal-Wallis ANOVA:

  • * P < 0.05;

  • P < 0.01. The significance of differences between women with and without diabetes for the corresponding menopausal status is also shown.