Table 2—

Clinical and biochemical variables and glucose and lipid metabolic parameters obtained before and after 6 months of treatment

Control group
Triple therapy group
BeforeAfterBeforeAfter
Body weight (kg)86 ± 587 ± 587 ± 791 ± 9
Systolic blood pressure (mmHg)129 ± 7132 ± 3140 ± 7147 ± 6
Diastolic blood pressure (mmHg)76 ± 479 ± 276 ± 378 ± 3
Fasting plasma FFA (mmol/l)0.67 ± 0.060.51 ± 0.05*0.70 ± 0.040.67 ± 0.06
Fasting plasma LDL cholesterol (mmol/l)3.0 ± 0.43.5 ± 0.42.8 ± 0.33.4 ± 0.5
Fasting plasma HDL cholesterol (mmol/l)1.14 ± 0.071.07 ± 0.081.46 ± 0.151.53 ± 0.16
Fasting plasma triglycerides (mmol/l)2.6 ± 0.52.1 ± 0.31.1 ± 0.21.3 ± 0.2
Hemoglobin (mmol/l)8.1 ± 0.38.1 ± 0.48.7 ± 0.48.0 ± 0.4
Alanin aminotransferase (units/l)27 ± 624 ± 529 ± 917 ± 4.0
Alkaline phosphatase (units/l)180 ± 17214 ± 19194 ± 13152 ± 8*
Basal serum insulin (pmol/l)104 ± 12100 ± 24187 ± 5876 ± 28
Clamp serum insulin (pmol/l)504 ± 47400 ± 25635 ± 102397 ± 36
Basal HGP mg · min−1 · m−281.6 ± 3.788.7 ± 5.282.1 ± 5.686.7 ± 6.3
Clamp HGP mg · min−1 · m−230.2 ± 2.721.4 ± 4.537.4 ± 7.322.0 ± 4.0
Si, 10−2 mg · min−1 · m−3 per pmol/l per mmol/l6.5 ± 1.16.3 ± 0.58.5 ± 1.310.3 ± 1.0§
Basal glucose oxidation mg · min−1 · m−259.9 ± 7.466.1 ± 9.843.8 ± 5.652.0 ± 7.7
Clamp glucose oxidation mg · min−1 · m−284.5 ± 11.082.7 ± 11.583.7 ± 10.0106.8 ± 5.5
Clamp glucose storage mg · min−1 · m−253.2 ± 12.368.9 ± 17.251.3 ± 16.867.5 ± 7.1
Basal lipid oxidation mg · min−1 · m−230.3 ± 4.734.1 ± 3.241.7 ± 4.739.3 ± 4.4
Clamp lipid oxidation mg · min−1 · m−222.8 ± 4.727.0 ± 2.623.6 ± 6.215.5 ± 3.7
  • Data are means ± SE. Si is calculated as Rd/(I × PG), where Rd is the tracer calculated rate of disappearance, I is the incremental serum insulin during the clamp, and PG is plasma glucose concentration.

  • * P < 0.01 before versus after;

  • P < 0.05 triple therapy versus control;

  • P < 0.05 before versus after;

  • § P < 0.01 triple therapy versus control.