Table 1—

Clinical and histological features in PCA+ versus PCA type 1 diabetic patients

PCA+PCAP
n (M/F)47 (26/21)41 (25/16)NS
Age (years)41 ± 1343 ± 13NS
Duration of diabetes (years)19 ± 1222 ± 10NS
GADA+37 (79)23 (56)0.038
H+/K+ ATPase (units/ml)234.7 ± 325.37.9 ± 10.50.007
HP+24 (51)23 (56)NS
Iron deficiency anemia15 (32)5 (12)0.04
Pernicious anemia11 (23)1 (2)0.005
Gastrin (ng/l)265 ± 292127 ± 690.027
Hypergastrinemia (gastrin > 110 ng/l)22 (47)9 (22)0.025
Hypochlorhydria (n tested 42)11/155/270.0008
Maximal acid output (mmol H+/h)7.8 ± 7.016.9 ± 10.40.004
Autoimmune atrophic gastritis27 (57)4 (10)<0.0001
HP-associated gastritis10 (21)17 (41)NS
Parietal cell mass (%)20 ± 1029 ± 6<0.0001
Corpus atrophy1 (0–3)0 (0–2)0.02
Corpus HP1 (0–3)0 (0–2)NS
Corpus inflammation1 (0–2)1 (0–2)NS
Corpus metaplasia0 (0–3)0 (0–2)NS
Corpus intestinal metaplasia11 (23)1 (2)0.004
Distribution of lymphocytic infiltration2 (0–3)2 (0–3)0.038
Degree of lymphocytic infiltration2 (0–4)2 (0–3)NS
Lymphocytic destruction of glands0 (0–3)0 (0–1)NS (0.06)
State of the oxyntic glands0 (0–2)0 (0–1)0.014
State of the intact parietal cells0 (0–1)0 (0–0)NS
ECL cell+7 (15)0 (0)0.013
B-cells (counts/mm2)1,461 ± 516698 ± 3790.031
T-cells (counts/mm2)645 ± 266278 ± 1470.032
  • Data are means ± SD, median (range), or n (%).