Table 2—

Comparison of clinical and histological features in type 1 diabetic patients with and without autoimmune gastritis

Autoimmune gastritisNo autoimmune gastritisP
n (M/F)31 (16/15)57 (34/23)NS
Age (years)44 ± 1241 ± 13NS
Duration of diabetes (years)20 ± 1220 ± 11NS
aTPO+10 (32)16 (28)NS
PCA+27 (87)20 (35)<0.0001
H+/K+ ATPase (units/ml)154.6 ± 121.021.5 ± 36.20.001
HP+13 (42)34 (60)NS
Gastrin (ng/l)333 ± 335131 ± 880.001
Vitamin B12 (pmol/l)319 ± 229376 ± 182NS
Red blood cell folic acid (nmol/l)923 ± 4171008 ± 369NS
Iron deficiency anemia12 (39)8 (14)0.015
Pernicious anemia8 (26)4 (7)0.022
Hypochlorhydria (n tested 42)10/126/300.0002
Maximal acid output (mmol H+/h)4.1 ± 3.614.3 ± 10.20.001
Parietal cell mass (%)15 ± 829 ± 4<0.0001
Corpus atrophy1 (0–3)0 (0–1)<0.0001
Corpus HP0 (0–1)0 (0–3)0.018
Corpus inflammation1 (1–2)1 (0–2)0.021
Corpus metaplasia0 (0–3)0 (0–1)0.013
Corpus metaplasia11 (35)1 (2)<0.0001
ECL cell+7 (23)0 (0)0.0004
B-cell (counts/mm2)1,595 ± 525834 ± 4180.03
T-cell (counts/mm2)639 ± 259395 ± 202NS
  • Data are means ± SD, median (range), or n (%).