Table 2

Association between hs-CRP and major depression

hs-CRP quintiles (interquartile range), mg/dL
1 (0.01–0.01)2 (0.05–0.06)3 (0.07–0.09)4 (0.12–0.18)5 (0.31–0.80)
Number of subjects1,153443584719674
Number with major depression3313162634
OR (95% CI) for major depression
 Age- and sex-adjusted model (model 1)1.09 (0.59–2.00)1.14 (0.54–2.40)1.00 (Ref.)1.33 (0.70–2.50)1.86 (1.01–3.42)
 Multivariable-adjusted model (model 2)*1.16 (0.63–2.13)1.14 (0.54–2.40)1.00 (Ref.)1.26 (0.67–2.39)1.70 (0.92–3.13)
 Multivariable-adjusted model (model 3)1.21 (0.66–2.24)1.14 (0.54–2.43)1.00 (Ref.)1.19 (0.63–2.25)1.58 (0.85–2.94)
  • *Model 2 adjusted for age, sex, and exercise.

  • †Model 3 adjusted for age, sex, smoking, type of diabetes therapy, diabetic nephropathy, arthritis, nonsteroidal anti-inflammatory drug use, and exercise (low, middle, and high intensity) (21).