Table 3—

Prevalence of high-risk genotypes and haplotypes in patients with LADA, those with adult-onset type 1 diabetes, and control subjects

HLA genotypes and haplotypesLADA (n = 50)LADA compared with control subjects
Adult-onset type 1 diabetes (n = 50)Adult-onset type 1 diabetes compared with control subjects
Control subjects (n = 336)LADA compared with adult-onset type 1 diabetes
P valueOR*P valueORP valueOR
DQB1*030217 (34)0.0013.2 (1.6–6.4)20 (40)0.00073.2 (1.6–6.4)49 (15)0.930.9 (0.4–2.5)
DR419 (38)0.00073.2 (1.6–6.3)25 (50)0.000063.8 (1.9–7.2)60 (18)0.701.2 (0.5–3.0)
DQB1*020121 (42)ND22 (44)NDND0.790.9 (0.4–2.2)
DR321 (42)0.012.3 (1.2–4.4)22 (44)0.0182.1 (1.1–4.0)85 (25)0.790.9 (0.4–2.2)
DR3/DR46 (12)0.033.8 (1.2–13.0)7 (14)0.0144.3 (1.3–13.6)9 (3)0.891.1 (0.2–5.1)
DQB1*0201/DQB1*03024 (8)ND7 (14)NDND0.891.1 (0.2–5.1)
DR4-DQB1*030217 (34)0.00063.5 (1.7–6.9)19 (38)0.00063.3 (1.7–6.5)47 (14)0.930.9 (0.3–2.5)
DR3/DR4-DQB1*03028 (16)0.044.4 (1.1–18.4)7 (14)0.00476.1 (1.7–21.4)6 (2)0.891.1 (0.2–5.1)
  • Data are n (%), unless otherwise indicated. Frequency differences were compared by logistic regression analyses, adjusted for age at diagnosis of diabetes and sex.

  • *

    * Odds ratio (95% CI). ND, not determined.