Table 1—

Clinical characteristics of the study subjects by p22 phox polymorphism

Subjects with type 2 diabetes
Nondiabetic subjects
CCTC+TTPCCTC+TTP
N (men/women)173 (108/65)27 (19/8)NS*182 (114/68)33 (18/15)NS*
Age (years)58.9 ± 7.857.6 ± 10.6NS42.8 ± 9.441.2 ± 10.4NS
Duration of diabetes (years)12.8 ± 8.610.3 ± 8.7NS
BMI (kg/m2)23.5 ± 4.424.5 ± 3.1NS22.7 ± 3.122.5 ± 2.9NS
Systolic blood pressure (mmHg)134 ± 15134 ± 15NS123 ± 15121 ± 14NS
Diastolic blood pressure (mmHg)77 ± 975 ± 10NS74 ± 9.871 ± 10NS
Total cholesterol (mmol/l)5.21 ± 0.915.30 ± 0.97NS5.21 ± 0.815.26 ± 0.83NS
Triglycerides (mmol/l)1.46 ± 0.701.86 ± 1.11NS1.28 ± 0.741.13 ± 0.57NS
HDL cholesterol (mmol/l)1.41 ± 0.431.44 ± 0.50NS1.57 ± 0.361.65 ± 0.37NS
LDL cholesterol (mmol/l)3.22 ± 0.973.06 ± 1.10NS2.99 ± 0.693.08 ± 0.69NS
HbA1c (%)7.57 ± 3.036.84 ± 1.43NS4.82 ± 0.474.66 ± 0.32NS
Fasting glucose (mmol/l)5.33 ± 0.635.11 ± 0.39NS
Fasting insulin (pmol/ml)64.2 ± 59.441.4 ± 15.60.0098
HOMA-R2.60 ± 2.561.58 ± 0.660.0066
8-OHdG (ng/ml)1.51 ± 0.751.12 ± 0.34NS1.29 ± 0.711.26 ± 0.27NS
Smoking (yes/no)50/1237/20NS*51/13110/23NS*
IMT (mm)1.31 ± 0.341.13 ± 0.310.00990.94 ± 0.300.85 ± 0.14NS
CHD (abnormal Q/angina/ myocardial infarction)10/2/72/0/1NS*
  • Data are means ± SD.

  • *

    * χ2 test was performed;

  • Mann-Whitney U test was performed.