Table 3—

Neuropathy symptom and change (NSC) scores

ScoreMean at onset (points)
Mean change (points)
Wilcoxon P value
ALA*PLAALAPLA
NSC—number9.410.1−4.2−2.2<0.001
NSC—severity18.420.5−11.1−7.2<0.001
NSC—change0.20.014.59.2<0.001
NSC Weakness—severity0.00.00.00.0NS
NSC Sensory—number7.27.6−3.3−1.4<0.001
NSC Sensory—severity14.916.4−9.4−5.7<0.001
NSC Sensory—change0.20.012.47.4<0.001
NSC(LL) Sensation—severity14.95.5−9.4−5.7<0.001
NSC(LL) Large-Fiber Sensation—severity2.83.1−1.2−0.6<0.001
NSC(LL) Small-Fiber Sensation—severity12.113.3−8.3−5.1<0.001
NSC(LL) Negative Sensation—severity2.73.5−1.2−0.70.043
NSC(LL) Positive Sensation—severity12.212.9−8.3−5.0<0.001
NSC(LL) Pain—severity10.010.6−7.3−4.6<0.001
NSC Autonomic—severity3.54.2−1.7−1.5NS
  • *

    * n = 60; PLA, placebo, n = 58.