Table 1—

Baseline characteristics

Losartan (+ CT)Placebo (+ CT)
n751762
Age (years)60 ± 760 ± 7
Male462 (61.5)494 (64.8)
Race
  Asian117 (15.6)135 (17.7)
  Black125 (16.6)105 (13.8)
  Caucasian358 (47.7)378 (49.6)
  Hispanic140 (18.6)136 (17.8)
  Other11 (1.5)8 (1.0)
Medical history
  Duration of diabetes ≥5 years676 (90.0)686 (90.0)
  BMI (kg/m2)*30 ± 629 ± 6
  Systolic blood pressure (mmHg)152 ± 19153 ± 20
  Diastolic blood pressure (mmHg)82 ± 1082 ± 11
  Use of antihypertensive drugs693 (92.3)721 (94.6)
  Currently smoking147 (19.6)130 (17.0)
  Lipid disorders234 (31.2)271 (35.6)
  Angina pectoris65 (8.7)75 (9.8)
  Myocardial infarction75 (10.0)94 (12.3)
  Coronary revascularization1 (0.1)1 (0.1)
  Stroke01 (0.1)
  Retinopathy494 (65.8)470 (61.7)
  Neuropathy375 (50.0)379 (49.7)
  Amputation65 (8.7)69 (9.1)
Laboratory
  Urine albumin:creatinine ratio (median, mg/g)1,2371,261
  Serum creatinine (mg/dl)1.9 ± 0.51.9 ± 0.5
  HbA1c (%)8.5 ± 1.78.4 ± 1.6
  Serum cholesterol (mg/dl)§
    Total227 ± 56229 ± 55
    LDL142 ± 47142 ± 45
    HDL45 ± 1645 ± 15
  Serum triglycerides (mg/dl)213 ± 180225 ± 200
  • Data are means ± SD or n (%).

  • *

    * BMI was calculated as weight (kilograms) divided by square of height (meters squared);

  • to convert to mg/mmol, multiply by 0.113;

  • to convert to μmol/l, multiply by 88.4;

  • §

    § to convert to mmol/l, multiply by 0.02586;

  • to convert to mmol/l, multiply by 0.01129.