Table 1—

Mortality and risk factor characteristics of study cohort at randomization and averaged across the 6 trial years by incident diabetes and incident NF-CVD groups (mortality follow-up through 1999)

Participants who did not develop diabetes or NF-CVDParticipants who developed diabetes but not NF-CVDParticipants who developed NF-CVD but not diabetesParticipants who developed both diabetes and NF-CVDP for group differences
Number in study cohort9,7411,122658124
Number (rate*) of total deaths2,930 (181)499 (286)342 (365)88 (555)<0.0001
Number (rate) of CVD deaths1,320 (82)245 (141)228 (243)53 (334)<0.0001
Number (rate) of CHD deaths883 (55)171 (98)177 (189)46 (290)<0.0001
Baseline characteristics
 Age (years)46.1 ± 6.047.1 ± 5.647.3 ± 5.848.5 ± 5.6<0.0001
 Black (%)79480.0005
 Heart rate (beats/min)70.4 ± 11.072.8 ± 11.671.3 ± 10.971.5 ± 11.6<0.0001
 Heart rate-adjusted QT interval408.7 ± 17.3410.2 ± 16.8411.1 ± 17.4410.3 ± 17.00.0003
 Fasting total cholesterol (mg/dl)239.7 ± 36.4238.4 ± 37.4249.2 ± 37.0246.9 ± 36.8<0.0001
 Fasting glucose (mg/dl)96.4 ± 9.9106.1 ± 10.796.5 ± 9.7104.7 ± 11.6<0.0001
 Proteinuria 1+ to 4+ (%)34420.33
 Drinks per week12.6 ± 12.112.8 ± 12.911.9 ± 12.710.7 ± 9.70.15
 Smoker (%)63627376<0.0001
 Cigarettes per day among smokers34.0 ± 15.333.0 ± 15.534.8 ± 14.135.3 ± 17.90.0002
 History of parental diabetes17261932<0.0001
 History of parental heart disease60606971<0.0001
Trial-averaged characteristics
 HDL cholesterol (mg/dl)43.1 ± 10.539.2 ± 10.240.2 ± 8.837.4 ± 9.0<0.0001
 LDL cholesterol (mg/dl)155.3 ± 30.4144.9 ± 34.1161.5 ± 28.9152.1 ± 34.5<0.0001
 Triglycerides (mg/dl)177.8 ± 97.8275.9 ± 214.7190.3 ± 90.2279.1 ± 181.4<0.0001
 Uric acid (mg/dl)6.8 ± 1.17.1 ± 1.26.8 ± 1.17.4 ± 1.1<0.0001
 BMI (kg/m2)27.3 ± 3.429.2 ± 3.827.1 ± 3.328.5 ± 3.7<0.0001
 Systolic blood pressure (mmHg)126.0 ± 11.0129.3 ± 10.7125.7 ± 11.1127.9 ± 12.2<0.0001
Other
 Smoker at sixth annual visit (%)42344332<0.0001
 During-trial thiazide use (%)53725974<0.0001
 During-trial β-blocker use (%)17294152<0.0001
  • Data are means ± SD unless otherwise indicated.

  • *

    * Rates are per 10,000 person-years; P values for mortality are from log-rank tests;

  • to convert to SI units: cholesterol, 1 mg/dl = 0.0259 mmol/l; glucose, 1 mg/dl = 0.0555 mmol/l; TG, 1 mg/dl = 0.0113 mmol/l; uric acid, 1 mg/dl = 59.48 μmol/l.