Table 2—

Baseline CVD risk factors according to tertile of baseline HOMA-IR among nondiabetic participants, the SHS (N = 2,283)

CVD risk factorHOMA-IR*
P
First tertileSecond tertileThird tertile
Age (years; mean ± SD)55.4 ± 8.155.6 ± 8.255.5 ± 8.00.853
Sex (% women)49.960.161.1<0.001
BMI (kg/m2; mean ± SD)25.6 ± 4.129.9 ± 4.933.8 ± 5.7<0.001
Waist circumference
 Men92.4 ± 9.1102.2 ± 9.38109.5 ± 11.7<0.001
 Women91.6 ± 12.7102.6 ± 13.1112.0 ± 13.2<0.001
Systolic blood pressure (mmHg)121 ± 19124 ± 17128 ± 18<0.001
Total cholesterol (mg/dl; mean ± SE)190 ± 1.37193 ± 1.34187 ± 1.300.003
Non-HDL cholesterol (mg/dl; mean ± SE)136 ± 1.94142 ± 1.90144 ± 1.850.015
LDL cholesterol (mg/dl; mean ± SE)112 ± 1.19111 ± 1.16106 ± 1.320.013
HDL cholesterol (mg/dl; mean ± SD)54 ± 1748 ± 1443 ± 11<0.001
Log (fibrinogen) (mg/dl; mean ± SD)5.59 ± 0.245.61 ± 0.255.64 ± 0.250.069
Triglycerides (mg/dl; mean ± SD)101 ± 58130 ± 73150 ± 124<0.001
Current smoking (%)55%38%28%<0.001
FG (mg/dl; mean ± SD)96 ± 10102 ± 10108 ± 9<0.001
FI (μU/ml; mean ± SD)5.9 ± 2.112.5 ± 2.428.0 ± 15.8<0.001
Albumin:creatinine ratio (% >30 mg/g)11.76.515.6<0.001
  • *

    * (FI [μU/ml] · FG [mmol/l])/22.5;

  • P values are tests for trend from generalized linear models or χ2 tests for trend for continuous and categorical variables, respectively;

  • means adjusted for study center.