Table 2

Cox regression analysis for the predictive value of serum OPN for incident microalbuminuria or progression to macroalbuminuria or ESRD

Incident microalbuminuriaProgression to macroalbuminuriaProgression to ESRD
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
Model 11.03 (1.01–1.05)0.03NSNS
Model 21.03 (1.00–1.05)0.03NS1.01 (1.00–1.02)0.02
Model 31.03 (1.01–1.05)0.009NS1.02 (1.02–1.03)<0.001
  • HR, hazard ratio.

  • Model 1 adjusted for sex, age, waist-to-hip ratio, current smoking, A1C, triglycerides, antihypertensive medication, eGFR, urinary AER, and hs-CRP.

  • Model 2 adjusted for sex, age, duration of diabetes, BMI, waist-to-hip ratio, current smoking, A1C, triglycerides, LDL cholesterol, systolic blood pressure, antihypertensive medication, eGFR, urinary AER, and hs-CRP.

  • Model 3 adjusted for the covariates in the Framingham risk score (sex, age, LDL cholesterol, HDL cholesterol, systolic blood pressure, diabetes, and smoking).