Table 1—

Clinical characteristics of 909 patients with type 1 diabetes in the DCCT/EDIC cohort

ParameterMenWomenP
n504405
Age (years)39.9 ± 6.739.2 ± 7.20.12
Duration of diabetes (years)17.1 ± 4.617.8 ± 4.90.03
BMI (kg/m2)27.2 ± 3.926.3 ± 4.30.002
Waist-to-hip circumference ratio0.9 ± 0.10.8 ± 0.7<0.0001
Systolic blood pressure (mmHg)123 ± 13116 ± 14<0.0001
Diastolic blood pressure (mmHg)77 ± 973 ± 9<0.0001
Total cholesterol (mg/dl)189 ± 37188 ± 340.43
Triglycerides (mg/dl)98 ± 7277 ± 49<0.0001
LDL cholesterol (mg/dl)118 ± 32110 ± 30<0.0001
HDL cholesterol (mg/dl)52 ± 1363 ± 15<0.0001
HbA1c (%)8.2 ± 1.38.2 ± 1.40.95
Mean HbA1c during DCCT (%)8.1 ± 1.38.1 ± 1.50.60
Albumin excretion rate (mg/24 h)133 ± 74991 ± 7570.40
Log albumin excretion rate (mg/24 h)2.7 ± 1.42.5 ± 1.20.01
ETDRS retinopathy score4.6 ± 3.34.4 ± 3.40.29
Average ankle-brachial index1.12 ± 0.121.09 ± 0.10<0.0009
Common carotid IMT (mm)0.69 ± 0.090.66 ± 0.08<0.0001
Internal carotid IMT (mm)0.71 ± 0.170.64 ± 0.16<0.0001
Intensive treatment subgroup during DCCT (n)50520.49
Smoking (n)19180.76
Hypertension (n)*4327<0.0001
Albumin excretion rate ≥40 mg/24 h (n)15120.11
Fibrinogen genotype (GG/GA/AA) (n)58/37/563/31/60.17
  • Data are as means ± SD.

  • *

    * Hypertension is defined as previously documented hypertension or blood pressure ≥140/90 mmHg at the time the blood sample was obtained for analysis of fibrinogen. P values in bold type are statistically significant.