Table 3—

Effects of discontinuous variables on the serum fibrinogen level in type 1 diabetes

Discontinuous variableNumber studiedFibrinogen level (mg/dl)P (ANOVA)P (ANCOVA)*
Sex0.00450.0006
 Men504300 ± 5
 Women405321 ± 5
Smoking status0.37420.1187
 Yes166316 ± 9
 No731308 ± 4
Hypertension0.02080.6608
 Yes323321 ± 6
 No576303 ± 4
HbA1c (by quartile)0.00010.0085
 <7.3%219288 ± 7
 7.3–7.9%224312 ± 7
 8.0–8.9%229310 ± 7
 ≥9.0%232328 ± 7
  • Data are means ± SE.

  • *

    * ANCOVA P value adjusts for effects of age, duration of diabetes, DCCT treatment group, BMI, waist-to-hip ratio, serum triglycerides, LDL cholesterol, and HDL cholesterol in all analyses, in addition to HbA1c, sex, hypertension, and smoking status when not considered to be the dependent variable.

  • Individuals are classified as hypertensive if taking antihypertensive medications with a history of hypertension plus individuals with a blood pressure of ≥140/90 at the clinic visit.