Baseline risk factor levels for CAD in both sexes, by first event, EDC 10-year follow-up
| Variable | No CAD | Angina | ECG ischemia | Hard CAD | Total CAD |
|---|---|---|---|---|---|
| n | 495 | 49 | 17 | 42 | 108 |
| Sex (% men) | 50.1 | 49.0 | 35.3 | 61.9 | 51.9 |
| Age (years) | 25.9 ± 7.3 | 33.4 ± 6.2‡ | 32.0 ± 9.1† | 32.9 ± 6.6‡ | 33.0 ± 6.8‡ |
| Duration (years) | 17.6 ± 6.9 | 25.1 ± 6.5‡ | 23.4 ± 8.8† | 25.4 ± 6.4‡ | 24.9 ± 6.9‡ |
| HbA1 (%) | 10.4 ± 1.8 | 9.9 ± 1.9 | 10.6 ± 1.4 | 10.7 ± 1.8 | 10.3 ± 1.8 |
| Insulin dose/kg BW | 0.81 ± 0.25 | 0.71 ± 0.18† | 0.76 ± 0.22 | 0.75 ± 0.31 | |
| Fibrinogen (mg/dl)§ | 280.1 ± 87.1 | 305.8 ± 77.9† | 302.1 ± 94.6 | 343.3 ± 97.2‡ | 319.6 ± 89.5‡ |
| WBC × 103/mm2¶ | 6.4 ± 1.8 | 7.1 ± 2.2* | 7.2 ± 2.4 | 8.1 ± 2.4‡ | 7.5 ± 2.3‡ |
| Triglycerides (mg/dl)§ | 99.8 ± 82.7 | 113.4 ± 67.6* | 145.8 ± 146.4 | 156.5 ± 80.1‡ | 134.4 ± 90.9‡ |
| Non-HDL cholesterol (mg/dl)¶ | 130.7 ± 38.3 | 151.0 ± 42.0‡ | 145.4 ± 59.7 | 174.7 ± 48.5‡ | 159.2 ± 48.8‡ |
| LDL cholesterol (mg/dl)¶ | 111.0 ± 30.8 | 125.3 ± 32.3† | 119.9 ± 53.0 | 147.0 ± 44.0‡ | 132.4 ± 41.8‡ |
| HDL cholesterol (mg/dl) | 54.8 ± 12.2 | 50.9 ± 13.0* | 51.3 ± 12.5 | 48.3 ± 9.8† | 50.0 ± 11.8‡ |
| ApoA1/HDL cholesterol | 2.6 ± 0.5 | 2.8 ± 0.6* | 2.9 ± 0.6* | 2.9 ± 0.5‡ | 2.9 ± 0.5‡ |
| Serum creatinine (mg/dl)§ | 0.96 ± 0.9 | 1.03 ± 0.5* | 1.1 ± 1.3 | 1.6 ± 1.6‡ | 1.3 ± 1.2† |
| Log median AER (μg/min)§ | 3.2 ± 1.8 | 4.2 ± 2.1† | 3.8 ± 2.3 | 5.9 ± 2.2‡ | 4.8 ± 2.3‡ |
| Systolic blood pressure (mmHg) | 111.1 ± 13.2 | 118.5 ± 14.1‡ | 113.8 ± 18.7 | 127.5 ± 21.1‡ | 121.3 ± 18.5‡ |
| Corrected QT interval | 407.1 ± 30.0 | 414.1 ± 25.9 | 418.0 ± 20.8 | 412.5 ± 29.6 | 414.1 ± 26.5* |
| Physical activity (kcal/week)§ | 2,790.9 ± 2,999.8 | 1,779.2 ± 2,176.4† | 2,288.6 ± 2,412.7 | 1,917.4 ± 1,766.7 | 1,916.9 ± 2,053.6† |
| Waist-to-hip ratio | 0.82 ± 0.07 | 0.84 ± 0.08* | 0.82 ± 0.08 | 0.86 ± 0.07‡ | 0.85 ± 0.07‡ |
| eGDR (mg · kg−1 · min−1)§ | 8.1 ± 1.8 | 7.3 ± 2.0† | 7.8 ± 1.9 | 6.4 ± 1.9‡ | 7.0 ± 2.0‡ |
| BDI§ | 6.8 ± 6.2 | 9.7 ± 7.1† | 3.9 ± 4.6 | 7.7 ± 5.7 | 8.1 ± 6.5* |
| Smoke ever (%) | 32.8 | 50.0* | 56.3 | 59.5† | 54.7‡ |
| Hypertension (%) | 9.9 | 34.7‡ | 11.8‖ | 42.9‡ | 34.3‡ |
| DSP (%) | 20.3 | 61.2‡ | 35.3‖ | 50.0‡ | 52.8‡ |
| E/I <1.10 (%) | 12.9 | 32.6† | 33.3*‖ | 47.1‡ | 37.9‡ |
| ON (%) | 17.2 | 38.8† | 23.5‖ | 69.0‡ | 48.1‡ |
| MA or ON (%) | 38.8 | 69.4‡ | 41.2 | 85.7‡ | 71.3‡ |
| ABI <0.8 or ABD 75+ (%) | 6.4 | 14.3 | 17.63 | 26.8‡‖ | 19.6‡ |
| eGDR <6.22 (mg · kg−1 · min−1) (%) | 14.1 | 22.4 | 18.8 | 56.1‡ | 34.9‡ |