Table 1—

Baseline risk factor levels for CAD in both sexes, by first event, EDC 10-year follow-up

VariableNo CADAnginaECG ischemiaHard CADTotal CAD
n495491742108
Sex (% men)50.149.035.361.951.9
Age (years)25.9 ± 7.333.4 ± 6.232.0 ± 9.132.9 ± 6.633.0 ± 6.8
Duration (years)17.6 ± 6.925.1 ± 6.523.4 ± 8.825.4 ± 6.424.9 ± 6.9
HbA1 (%)10.4 ± 1.89.9 ± 1.910.6 ± 1.410.7 ± 1.810.3 ± 1.8
Insulin dose/kg BW0.81 ± 0.250.71 ± 0.180.76 ± 0.220.75 ± 0.31
Fibrinogen (mg/dl)§280.1 ± 87.1305.8 ± 77.9302.1 ± 94.6343.3 ± 97.2319.6 ± 89.5
WBC × 103/mm26.4 ± 1.87.1 ± 2.2*7.2 ± 2.48.1 ± 2.47.5 ± 2.3
Triglycerides (mg/dl)§99.8 ± 82.7113.4 ± 67.6*145.8 ± 146.4156.5 ± 80.1134.4 ± 90.9
Non-HDL cholesterol (mg/dl)130.7 ± 38.3151.0 ± 42.0145.4 ± 59.7174.7 ± 48.5159.2 ± 48.8
LDL cholesterol (mg/dl)111.0 ± 30.8125.3 ± 32.3119.9 ± 53.0147.0 ± 44.0132.4 ± 41.8
HDL cholesterol (mg/dl)54.8 ± 12.250.9 ± 13.0*51.3 ± 12.548.3 ± 9.850.0 ± 11.8
ApoA1/HDL cholesterol2.6 ± 0.52.8 ± 0.6*2.9 ± 0.6*2.9 ± 0.52.9 ± 0.5
Serum creatinine (mg/dl)§0.96 ± 0.91.03 ± 0.5*1.1 ± 1.31.6 ± 1.61.3 ± 1.2
Log median AER (μg/min)§3.2 ± 1.84.2 ± 2.13.8 ± 2.35.9 ± 2.24.8 ± 2.3
Systolic blood pressure (mmHg)111.1 ± 13.2118.5 ± 14.1113.8 ± 18.7127.5 ± 21.1121.3 ± 18.5
Corrected QT interval407.1 ± 30.0414.1 ± 25.9418.0 ± 20.8412.5 ± 29.6414.1 ± 26.5*
Physical activity (kcal/week)§2,790.9 ± 2,999.81,779.2 ± 2,176.42,288.6 ± 2,412.71,917.4 ± 1,766.71,916.9 ± 2,053.6
Waist-to-hip ratio0.82 ± 0.070.84 ± 0.08*0.82 ± 0.080.86 ± 0.070.85 ± 0.07
eGDR (mg · kg−1 · min−1)§8.1 ± 1.87.3 ± 2.07.8 ± 1.96.4 ± 1.97.0 ± 2.0
BDI§6.8 ± 6.29.7 ± 7.13.9 ± 4.67.7 ± 5.78.1 ± 6.5*
Smoke ever (%)32.850.0*56.359.554.7
Hypertension (%)9.934.711.842.934.3
DSP (%)20.361.235.350.052.8
E/I <1.10 (%)12.932.633.3*47.137.9
ON (%)17.238.823.569.048.1
MA or ON (%)38.869.441.285.771.3
ABI <0.8 or ABD 75+ (%)6.414.317.6326.819.6
eGDR <6.22 (mg · kg−1 · min−1) (%)14.122.418.856.134.9
  • Data are means ± SD or prevalence (%). Comparisons with no CAD:

  • *

    * P < 0.05;

  • P < 0.01;

  • P < 0.001.

  • §

    § Mann-Whitney U test;

  • Fisher’s exact test;

  • log transformed before student’s t test.