Table 5—

Effects of G−455→A fibrinogen gene polymorphism on plasma fibrinogen level and vascular complications in type 1 diabetes

Parameter and genotypeNumber of patientsMeanSEP (ANOVA)P (ANCOVA)*
Plasma fibrinogen level (mg/dl)0.6510.416*
Log albumin excretion rate (mg/24h)0.5800.548*
ETDRS retinopathy score (grade 1–23)0.5270.537*
Average ABI0.2780.299
Common carotid IMT (mm)0.9870.928*
Internal carotid IMT (mm)0.0500.045*
  • *

    * ANCOVA for fibrinogen level adjusted for age, sex, BMI, HbA1c, and smoking status; ANCOVAs for log albumin excretion rate, ETDRS score, common carotid IMT, and internal carotid IMT adjusted for age, sex, DCCT treatment group, BMI, and HbA1c level. Values in bold type are statistically significant.