Table 5—

Effects of G−455→A fibrinogen gene polymorphism on plasma fibrinogen level and vascular complications in type 1 diabetes

Parameter and genotypeNumber of patientsMeanSEP (ANOVA)P (ANCOVA)*
Plasma fibrinogen level (mg/dl)0.6510.416*
 GG4443075
 GA2563147
 AA4130217
Log albumin excretion rate (mg/24h)0.5800.548*
 GG4382.60.1
 GA2562.60.1
 AA402.80.2
ETDRS retinopathy score (grade 1–23)0.5270.537*
 GG4424.60.2
 GA2524.30.2
 AA404.80.5
Average ABI0.2780.299
 GG4381.100.005
 GA3541.110.007
 AA401.120.018
Common carotid IMT (mm)0.9870.928*
 GG4250.6770.004
 GA2470.6780.006
 AA390.6760.014
Internal carotid IMT (mm)0.0500.045*
 GG4250.6870.008
 GA2470.6590.010
 AA390.6420.026
  • *

    * ANCOVA for fibrinogen level adjusted for age, sex, BMI, HbA1c, and smoking status; ANCOVAs for log albumin excretion rate, ETDRS score, common carotid IMT, and internal carotid IMT adjusted for age, sex, DCCT treatment group, BMI, and HbA1c level. Values in bold type are statistically significant.