Table 2—

Changes in metabolic parameters from baseline values over time

Treatment time (months)
Baseline122436Last
HbA1c [% (n)]
 Losartan8.53 (742)8.54 (629)8.55 (498)8.33 (285)8.36 (171)
 Placebo8.43 (754)8.53 (604)8.51 (465)8.36 (238)8.47 (129)
Total cholesterol [mg/dl (n)]
 Losartan227.42 (743)213.50 (644)*205.32 (523)196.39 (310)*195.42 (74)
 Placebo228.69 (755)225.43 (637)211.47 (500)207.33 (271)205.17 (52)
HDL [mg/dl (n)]
 Losartan45.20 (739)45.91 (639)45.19 (521)*42.40 (311)41.36 (74)
 Placebo44.92 (752)47.60 (633)47.31 (499)44.10 (271)41.60 (50)
LDL [mg/dl (n)]
 Losartan142.15 (676)126.07 (588)*120.18 (484)115.47 (298)111.67 (69)
 Placebo142.31 (683)134.01 (573)124.81 (463)122.22 (248)119.13 (46)
Triglycerides [mg/dl (n)]
 Losartan212.80 (743)212.11 (643)205.10 (523)197.72 (310)219.78 (74)
 Placebo225.17 (755)226.93 (637)205.77 (500)211.75 (271)223.64 (50)
Lp(a) [mg/dl (n)]
 Losartan41.35 (482)*43.52 (309)NDNDND
 Placebo35.91 (481)42.20 (321)NDNDND
Serum K+ [mEq/l (n)]
 Losartan4.59 (751)4.77 (635)*4.80 (504)*4.78 (288)*4.78 (226)*
 Placebo4.62 (762)4.55 (616)4.55 (483)4.53 (244)4.49 (187)
Uric acid [mg/dl (n)]
 Losartan6.70 (751)6.95 (635)7.24 (509)*7.51 (288)7.59 (226)
 Placebo6.71 (762)7.09 (620)7.57 (485)7.59 (244)7.68 (187)
  • *

    * P < 0.05, losartan vs. placebo. ND, not determined.