Table 2—

Laboratory data in hypertensive type 1 diabetic patients with diabetic nephropathy and homozygosity for the I or D allele of ACE/ID polymorphism during 36 months of treatment with losartan 100 mg

Baseline
Follow-up
IIDDIIDD
Hemoglobin (mmol/l)8.6 ± 0.28.9 ± 0.28.3 ± 0.28.4 ± 0.2
HbA1c (%)8.7 ± 0.29.0 ± 0.29.1 ± 0.29.4 ± 0.2
Serum potassium (mmol/l)4.2 ± 0.14.2 ± 0.14.1 ± 0.14.1 ± 0.1
Serum creatinine (μmol/l)103 ± 4107 ± 7118 ± 6114 ± 8
Serum cholesterol (mmol/l)5.0 ± 0.15.4 ± 0.25.0 ± 0.15.2 ± 0.2
Serum HDL cholesterol (mmol/l)1.6 ± 0.11.6 ± 0.11.6 ± 0.11.7 ± 0.1
Serum albumin (g/l)37 ± 136 ± 138 ± 138 ± 1
Serum renin (μU/ml)*40 ± 2738 ± 22112 ± 25141 ± 52
Serum ACE (IU/l)*16 ± 125 ± 116 ± 125 ± 1
Plasma angiotensin II (pmol/l)*§9 ± 116 ± 329 ± 933 ± 1
Plasma aldosterone (pg/ml)*67 ± 2097 ± 3462 ± 1972 ± 11
Dietary protein intake (g · kg−1 · 24 h)1.2 ± 0.11.0 ± 0.11.1 ± 0.11.0 ± 0.1
Extracellular volume (I/1.73 m2)14.0 ± 0.514.2 ± 0.413.2 ± 0.414.0 ± 0.3
Urinary sodium (mmol/24 h)162 ± 9139 ± 11158 ± 9156 ± 8
  • Data are means ± SE.

  • *

    * Geometric means ± SE.

  • P < 0.05 vs. baseline;

  • P < 0.05 II vs. DD;

  • §

    § n = 18 II + 13 DD.