Table 2—

The ROC curve area for surrogate end points measured after 2, 4, or 8 weeks for a 12- or 20-week healed outcome

SurrogateWoundEnd pointROC curve
Week 2Week 4Week 8
Log ratePrimaryWeek 120.730.780.85
Percent changePrimaryWeek 120.730.790.85
Ratio of log areasPrimaryWeek 120.740.790.86
Log rateAllWeek 120.750.790.85
Percent changeAllWeek 120.750.800.86
Ratio of log areasAllWeek 120.760.800.86
Log ratePrimaryWeek 200.690.730.77
Percent changePrimaryWeek 200.690.730.77
Ratio of log areasPrimaryWeek 200.690.730.78
Log rateAllWeek 200.720.760.78
Percent changeAllWeek 200.720.760.78
Ratio of log areasAllWeek 200.720.760.79