Table 2—

The ROC curve area for surrogate end points measured after 2, 4, or 8 weeks for a 12- or 20-week healed outcome

Surrogate	Wound	End point	ROC curve
Surrogate	Wound	End point				Week 2	Week 4	Week 8
Log rate	Primary	Week 12	0.73	0.78	0.85
Percent change	Primary	Week 12	0.73	0.79	0.85
Ratio of log areas	Primary	Week 12	0.74	0.79	0.86
Log rate	All	Week 12	0.75	0.79	0.85
Percent change	All	Week 12	0.75	0.80	0.86
Ratio of log areas	All	Week 12	0.76	0.80	0.86
Log rate	Primary	Week 20	0.69	0.73	0.77
Percent change	Primary	Week 20	0.69	0.73	0.77
Ratio of log areas	Primary	Week 20	0.69	0.73	0.78
Log rate	All	Week 20	0.72	0.76	0.78
Percent change	All	Week 20	0.72	0.76	0.78
Ratio of log areas	All	Week 20	0.72	0.76	0.79