Table 3—

History of type 2 diabetes and HRs of invasive breast cancer subtypes among participants of the Nurses’ Health Study, 1976–1998

Breast cancerNo diabetes
Type 2 diabetes
Breast cancer cases (n)Person-yearsHRBreast cancer cases (n)Person-yearsAge-adjusted HR (95% CI)Covariate-adjusted HR (95% CI)*
Estrogen receptor-positive breast cancer2,7942,308,9351.012159,2401.16 (0.97–1.40)1.22 (1.01–1.47)
Estrogen receptor-negative breast cancer9572,309,0881.03259,3041.06 (0.74–1.51)1.13 (0.79–1.62)
Fatal breast cancer1,0542,351,5471.04661,3331.13 (0.84–1.52)0.98 (0.72–1.32)
  • *

    * HR and 95% CI adjusted for age, family history of breast cancer, history of benign breast disease, height, BMI at age 18 years, current BMI, age at menarche, parity, age at first child’s birth, menopausal status, age at menopause, use of postmenopausal hormones, physical activity, and alcohol consumption;

  • receptor status was not known for all breast cancer cases.