Table 2—

Costs of DPN and its complications in the U.S.

Health stateEstimated cost ($)References
Mean weekly cost
Painful symptomatic DPN$5.90*(12)
Foot ulcer
Not infected$178.97(12)
With cellulitis$472.73(12)
With osteomyelitis$876.52(11, 12)
Total event cost
Amputation
Toe$22,702.65(11)
Foot$42,673.04(11)
Leg$51,280.94(11)
  • Price year: 2001.

  • *

    * Typical weekly cost of a tricyclic antidepressant.

  • Gauze dressing two times a day. Mean numbers of weekly outpatient clinic attendances: 0.5 (no deep infection), one (with cellulitis), and 1.5 (with osteomyelitis). Proportions of patients receiving nurse home visits: 25% (no deep infection), 50% (with cellulitis), and 75% (with osteomyelitis). Mean numbers of weekly nurse home visits: three (no deep infection) and five (with cellulitis or osteomyelitis). Drugs received: cephalexin (500 mg four times a day; 50% of patients with no deep infection), clindamycin (300 mg three times a day; 50% of patients with no deep infection and all patients with a foot ulcer accompanied by cellulitis or osteomyelitis), and ciprofloxacin (500 mg two times a day; all patients with a foot ulcer accompanied by cellulitis, 400 mg two times a day; all patients with a foot ulcer accompanied by osteomyelitis).

  • Assumed cost of prosthetic leg: $15,000.