Table 3—

Crude and adjusted associations of CRP, IL-6, TNF-α, and the general score of inflammatory markers with markers of endothelial dysfunction

SDCRP
IL-6
TNF-α
General score of inflammatory markers
st(b)Pst(b)Pst(b)Pst(b)P
n515515508508
Soluble VCAM-1 (ng/ml)
 Crude0.100.0190.210.00010.490.00010.40<0.0001
 Adjusted1310.060.1770.140.0020.40<0.00010.28<0.0001
Soluble E-selectin, ng/ml
 Crude0.120.0070.180.00010.230.00010.24<0.0001
 Adjusted150.120.0050.170.00010.130.0010.19<0.0001
Adjusted model (R2)*24.115.242.936.0
  • Standardized regression coefficient st(b), i.e., expressed per 1 SD of the independent variable, and P obtained by linear regression analyses with the inflammatory markers; CRP, IL-6, TNF-α, and the general score of inflammatory markers as dependent and soluble VCAM-1 and soluble E-selectin as independent variables. Adjusted model includes the variables sex, age, duration of diabetes, HbA1c, pentosidine, BMI, waist circumference, HDL cholesterol, LDL cholesterol, triglycerides, systolic blood pressure, and pack-years of smoking.

  • *

    * R2 represents the percentage of variability of the dependent variable explained by the variables in the model including both VCAM-1 and E-selectin.