Table 1—

Effect of adding candesartan 16 mg o.d. to maximal recommended doses of ACEI (enalapril/lisinopril 40 mg daily) on kidney function and ABP in 20 patients with type 2 diabetes and diabetic nephropathy

ACEI + placeboACEI + candesartan 16 mgMean difference (95% CI)*P* value
Albuminuria (mg/24 h)706 (349–1,219)508 (228–909)28% (17–38)<0.001
Blood pressure (mmHg)
 24-h138 (3)/72 (2)135 (3)/70 (2)3 (−2 to 8)/2 (−2 to 5)0.21/0.38
 Day (7:00 a.m. to 11:00 p.m.)142 (3)/74 (2)139 (3)/72 (2)3 (−2 to 7)/3 (−2 to 7)0.32/0.31
 Night (11:00 p.m. to 7:00 a.m.)131 (4)/67 (2)126 (4)/65 (3)5 (−2 to 11)/2 (−3 to 7)0.16/0.51
GFR (ml · min−1 · 1.73 m−2)77 (6)74 (5)4 (−1, 9)0.10
Plasma creatinine (μmol/l)121 (10)123 (10)2 (−7 to 10)0.66
Plasma renin (mU/l)42 (1)53 (1)−24% (−60 to 12)0.19
Plasma potassium (mmol/l)4.0 (0.1)4.2 (0.1)−0.13 (−0.3 to 0.1)0.13
HbA1c (%)7.9 (0.2)8.1 (0.2)−0.1 (−0.1 to 0.4)0.31
Cholesterol (mmol/l)4.5 (0.2)4.6 (0.2)−0.1 (−0.2 to 0.4)0.60
Urinary sodium (mmol/24 h)195 (13)188 (12)6 (−19 to 32)0.63
Protein intake (g · kg−1 · 24 h−1)0.92 (0.06)0.93 (0.04)−0.01 (−0.07 to 0.07)0.94
  • Data are means (SE).

  • *

    * Mean difference of (ACEI + placebo) − (ACEI + candesartan 16 mg);

  • geometric mean (IQR).