Table 1

Participant baseline characteristics based on total serum hs-CRP concentration quartiles

Allhs-CRP quartiles
First quartileSecond quartileThird quartileFourth quartile
n = 2,518n = 819n = 454n = 650n = 595P value
hs-CRP (nmol/L)6.6 (1.0–15.2)1.0 (1.0–1.0)5.7 (4.8–6.7)10.5 (8.6–12.4)30.5 (21.0–54.3)
Age (years)66.1 (10.9)66.7 (10.1)66.7 (10.6)65.4 (10.8)65.8 (12.2)0.0725
Female (%)37.536.434.638.340.50.208
BMI (kg/m2)24.6 (4.0)23.2 (3.4)24.4 (3.4)25.2 (3.8)25.9 (4.9)<0.001
Systolic blood pressure (mmHg)137.7 (17.9)137.8 (18.1)139.2 (17.4)138.0 (17.7)136.3 (17.9)0.0743
Diastolic blood pressure (mmHg)73.4 (12.0)72.2 (11.7)74.1 (11.3)73.9 (12.3)73.8 (12.5)0.0063
HDL (mmol/L)1.44 (0.40)1.55 (0.39)1.42 (0.38)1.39 (0.38)1.37 (0.39)<0.001
LDL (mmol/L)2.65 (0.72)2.57 (0.69)2.62 (0.69)2.72 (0.75)2.70 (0.74)<0.001
Triglyceride (mmol/L)1.73 (1.14)1.46 (0.86)1.82 (1.16)1.86 (1.07)1.88 (1.43)<0.001
Creatinine (µmol/L)67.6 (19.7)65.9 (18.3)68.4 (19.7)67.7 (19.9)69.2 (21.3)0.012
eGFR (mL/min/1.73 m2)75.2 (22)76.9 (21.4)75.2 (21)75.2 (21.6)72.9 (23.6)0.019
Uric acid (µmol/L)325.6 (64.1)303.3 (84.9)310.8 (81.7)316.0 (81.7)325.6 (84.1)<0.001
HbA1c
 NGSP (%)7.5 (1.1)7.2 (1.0)7.5 (1.1)7.6 (1.2)7.6 (1.3)<0.001
 IFCC (mmol/mol)57.6 (12.1)55.3 (10.7)58.0 (11.8)58.7 (12.2)59.2 (13.3)<0.001
UACR (mg/mmol)5.81 (6.8)5.17 (6.20)5.50 (6.36)6.00 (6.90)6.74 (7.50)<0.001
Smoking (%)0.296
 Never42.643.741.743.540.8
 Past40.741.439.538.143.7
 Current16.714.918.818.515.5
Exercise (IPAQ category) (%)<0.001
 Low36.429.935.537.245.0
 Moderate31.234.532.928.927.6
 High32.535.631.633.927.4
Past history of cardiovascular disease (%)15.816.213.714.318.40.130
Past history of cancer (%)9.710.18.69.410.10.804
Past history of arthritis (%)0.280.120.440.310.340.743
Diabetic retinopathy (%)48.550.146.846.749.30.500
NSAID use (%)23.221.620.921.928.40.007
ACE-I use (%)5.96.65.66.04.90.605
ARB use (%)36.732.536.839.439.50.016
Statin use (%)44.145.443.045.741.50.376
  • †Median and interquartile range.