Table 4

Association between serum hs-CRP concentration and progression of diabetic nephropathy (shift from microalbuminuria to macroalbuminuria)

hs-CRP concentration quartiles
n = 344n = 203n = 301n = 318P value for trend
Median of hs-CRP (nmol/L)1.05.710.530.5
Interquartile range of hs-CRP (nmol/L)1.0–1.04.8–6.78.6–12.421.0–54.3
HR for development (95% CI)
 Crude modelRef0.65 (0.37–1.15)1.26 (0.72–2.18)1.18 (0.61–2.26)0.404
 Age- and sex-adjusted modelRef0.64 (0.35–1.17)1.25 (0.68–2.33)1.18 (0.58–2.39)0.430
 Multivariable-adjusted model*Ref0.59 (0.33–1.05)1.14 (0.69–1.91)1.03 (0.55–1.91)0.575
  • *Adjusted for age, sex, BMI, exercise, smoking, systolic blood pressure, diastolic blood pressure, HDL, LDL, triglyceride, serum creatinine, eGFR, serum uric acid, ACE-I use, ARB use, statin use, HbA1c levels, past history of cardiovascular disease, past history of cancer, history of arthritis, NSAID use, and diabetic retinopathy.