ANCOVA models showing the differences associated with treatment with pioglitazone in CRP, PWV, and adiponectin
| Variables with pioglitazone treatment | Covariates | Regression coefficient (SEM) | P value |
|---|---|---|---|
| ΔCRP | Unadjusted | −0.018 (0.010) | 0.0262 |
| Adjusted for ΔHbA1c | −0.041 (0.013) | 0.0015 | |
| ΔHOMA-IR | −0.027 (0.010) | 0.0117 | |
| ΔBMI | −0.042 (0.010) | 0.0001 | |
| ΔPWV | Unadjusted | −51.94 (21.61) | 0.0180 |
| Adjusted for ΔHbA1c | −50.64 (27.99) | 0.0423 | |
| ΔHOMA-IR | −47.03 (23.31) | 0.0463 | |
| ΔsBP and ΔdBP | −69.49 (26.87) | 0.0112 | |
| ΔLDL | −54.29 (21.89) | 0.0147 | |
| ΔTriglycerides | −49.89 (21.75) | 0.0238 | |
| ΔCRP | −34.56 (23.12) | 0.1381 | |
| ΔAdiponectin | −29.99 (22.47) | 0.1850 | |
| ΔAdiponectin | Unadjusted | 1.808 (0.474) | 0.0002 |
| Adjusted for ΔHbAA1c | 1.522 (0.616) | 0.0151 | |
| ΔHOMA-IR | 0.547 (0.147) | 0.0003 |
Changes in variables are indicated by subtracting the pretreatment value from the post-treatment value.