Table 3

Estimated effects (HR or coefficient) of the body weight dynamics on diabetes incidence and cardiometabolic outcomes

Diabetes incidenceFasting glucose (mg/dL)HOMA-IRTriglycerides (mg/dL)SBP (mmHg)
HR95% CIPβ95% CIPβ95% CIPβ95% CIPβ95% CIP
BL weight1.021.01, 1.03<0.010.080.04, 0.120.010.040.02, 0.05<0.010.10−0.11, 0.300.360.090.05, 0.12<0.01
BL to 1 month0.930.86, 1.000.05−0.47−0.75, 0.20<0.01−0.28−0.37, 0.19<0.01−1.34−2.83, 0.140.08−0.35−0.64, 0.070.01
BL to 3 months0.910.86, 0.97<0.01−0.67−0.86, −0.47<0.01−0.27−0.33, −0.21<0.01−1.77−2.81, −0.73<0.01−0.37−0.56, −0.17<0.01
BL to 6 months0.940.90, 0.98<0.01−0.59−0.72, −0.46<0.01−0.22−0.26, −0.18<0.01−1.68−2.38, −0.99<0.01−0.35−0.48, −0.21<0.01
BL to 2 years0.900.87, 0.93<0.01−0.57−0.66, −0.48<0.01−0.20−0.23, −0.17<0.01−2.27−2.76, −1.78<0.01−0.30−0.40, −0.21<0.01
Last 6 months0.950.89, 1.010.12−0.22−0.45, 0.010.06−0.11−0.18, −0.04<0.01−1.85−3.07, −0.64<0.01−0.15−0.39, 0.080.19
6 months to 2 years0.910.88, 0.95<0.01−0.46−0.58, −0.33<0.01−0.15−0.19, −0.11<0.01−2.38−3.03, −1.72<0.01−0.20−0.33, −0.07<0.01
5-lb cycles (n)1.331.12, 1.58<0.010.910.17, 1.650.020.250.01, 0.490.042.57−1.35, 6.500.200.940.19, 1.680.01
Average weight in 2 years1.051.03, 1.07<0.010.300.22, 0.38<0.010.140.10, 0.16<0.010.680.26, 1.10<0.010.260.18, 0.34<0.01
  • BL, baseline. The P values are output from individual regressions for the specific outcome and weight metric combination without adjustments for multiple tests. All weight measures are in kilograms except for number of 5-lb weight cycles.