Table 3—

Risk of type 2 diabetes by thirds of birth weight and BMI*

Adjusted for sexAdjusted for sex and BMI gain by 23 yearsAdjusted for sex and BMI at 23 years
Birth weight
 Lowest third1.71 (0.9–3.2)0.41 (0.2–0.8)2.03 (1.1–3.9)
 Middle third1.07 (0.5–2.0)0.55 (0.3–1.1)1.22 (0.6–2.5)
 Upper thirdreferencereferencereference
 Per 1-SD increase0.76 (0.6–0.99)1.55 (1.1–2.1)0.71 (0.5–0.9)
 Test for trendP = 0.04P = 0.005P = 0.01
BMI at age 7 years
 Lowest third2.84 (1.2–6.9)1.72 (0.7–4.1)3.47 (1.5–8.2)
 Middle thirdreferencereferencereference
 Upper third3.97 (1.7–9.1)5.18 (2.2–11.9)1.97 (0.8–4.7)
 Per 1-SD increase1.44 (1.2–1.7)2.03 (1.6–2.5)0.90 (0.7–1.1)
 Test for trendP < 0.001P < 0.001P = 0.37
 Test for curvatureP = 0.26P = 0.41P = 0.41
BMI at age 11 years
 Lowest third1.73 (0.8–4.0)1.64 (0.7–3.8)2.85 (1.3–6.5)
 Middle thirdreferencereferencereference
 Upper third3.59 (1.7–7.5)4.96 (2.3–10.6)1.57 (0.7–3.3)
 Per 1-SD increase1.78 (1.5–2.1)2.25 (1.9–2.7)1.06 (0.8–1.3)
 Test for trendP < 0.001P < 0.001P = 0.62
 Test for curvatureP = 0.99P = 0.85P = 0.86
BMI at age 16 years
 Lowest third0.62 (0.2–1.7)0.54 (0.2–1.5)0.93 (0.3–2.6)
 Middle thirdreferencereferencereference
 Upper third4.18 (2.1–8.4)4.53 (2.3–9.1)1.65 (0.8–3.5)
 Per 1-SD increase2.04 (1.7–2.4)2.34 (2.0–2.8)1.21 (0.9–1.6)
 Test for trendP < 0.001P < 0.001P = 0.16
BMI at age 23 years
 Lowest third0.10 (0.01–0.78)
 Middle thirdreference
 Upper third4.45 (2.3–8.9)
 Per 1-SD increase2.25 (1.9–2.6)
 Test for trendP < 0.001
  • Data are OR (95% CI).

  • *

    * Numbers of subjects same as in Table 2. Birth weight standardized for gestational age and sex, BMI standardized for sex.