Table 2—

Association between nonadherence levels and outcomes

Characteristics/outcome of interestHbA1cLDL cholesterolSBP
n308287384
Pearson’s correlation (CMG)*0.250.320.16
Spearman’s correlation (CMG)*0.210.300.15
Outcome levels (means ± SD)
    Nonadherent patients8.5 ± 1.6§124 ± 34.1§143 ± 12.9§
    Adherent patients8.0 ± 1.2103 ± 28.1138 ± 12.4
  • *

    * HbA1c levels were correlated with nonadherence to metformin, LDL levels with nonadherence to statins, and SBP levels with nonadherence to ACE inhibitors. CMG indicates the proportion of days with gaps in medication refills over the days in the observation period.

  • P < 0.01.

  • Nonadherence is defined as CMG >20%.

  • §

    § P < 0.01 for differences between nonadherent and adherent patients.