Table 4—

Multivariate* linear regression analysis of inflammatory markers on HOMA-IR by sex and chronic kidney disease

Variable (1 SD)Sex
Chronic kidney disease
MenWomenP for interactionNoYesP for interaction
n2,9213,0125,752182
Ferritin (126.1 ng/ml)0.08 (0.00–0.15)0.14 (0.00–0.28)0.9700.07 (0.004–0.13)§0.08 (−0.09–0.25)0.162
Uric acid (1.4 mg/dl)0.12 (0.01–0.24)§0.23 (0.14–0.33)0.4940.07 (0.004–0.14)§0.31 (0.08–0.54)0.232
White blood cell count (2.2 × 109/l)0.13 (0.02–0.25)§0.19 (0.09–0.29)0.5920.15 (0.08–0.22)0.34 (0.04–0.65)§0.082
Fibrinogen (80.6 mg/dl)0.11 (0.02–0.19)§0.13 (0.02–0.24)§0.8680.10 (0.03–0.18)0.36 (0.15–0.56)0.094
Detectable C-reactive protein−0.04 (−0.32 to 0.24)0.10 (−0.08 to 0.28)0.6650.04 (−0.11 to 0.20)0.26 (−0.54 to 1.07)0.102
Clinically elevated0.56 (−0.05 to 1.18)0.78 (0.28–1.28)0.65 (0.22–1.09)0.67 (−0.13 to 1.46)
  • Data are β (95% CI).

  • *

    * Adjusted for age, sex, race, education, physical activity, current and former smoking, alcohol intake, NSAID use in the past month, systolic blood pressure, BMI, waist circumference, serum total cholesterol, and triglycerides.

  • Chronic kidney disease was defined as estimated GFR <60 ml · min−1 · 1.73m−2.

  • Detectable C-reactive protein level: 0.22–0.99 mg/dl; clinically elevated C-reactive protein level: ≥1.0 mg/dl.

  • §

    § P < 0.05;

  • P < 0.01;

  • P < 0.001.