Table 2—

RH of type 2 diabetes over 6 years of follow-up by quartile of depressive symptoms for 11,615 individuals age 48–67 years

Quartile of depressive symptoms
P value for trend
Quartile 1Quartile 2Quartile 3Quartile 4
Model 1: adjusted for age, race, ARIC center, education, and sex1.01.22 (0.99–1.51)1.31 (0.89–1.43)1.63 (1.31–2.02)<0.0001
Model 2: adjusted for metabolic covariates*1.01.13 (0.9–1.40)1.06 (0.84–1.35)1.38 (1.10–1.73)0.0071
Model 3: adjusted for lifestyle covariates1.01.20 (0.97–1.48)1.09 (0.86–1.38)1.51 (1.21–1.89)0.0005
Model 4: adjusted for lifestyle covariates and BMI1.01.16 (0.94–1.43)1.02 (0.81–1.30)1.28 (1.02–1.60)0.06
Model 5: adjusted for metabolic and lifestyle covariates§1.01.12 (0.90–1.39)1.03 (0.81–1.31)1.31 (1.04–1.64)0.04
  • *

    * Model 2: adjusted for age, race, ARIC center, education, sex, fasting insulin, fasting glucose, log triglycerides, HDL cholesterol, BMI, waist-to-hip ratio, and systolic blood pressure.

  • Model 3: adjusted for age, race, ARIC center, sex, education, physical activity, total caloric intake, and smoking status.

  • Model 4: adjusted for age, race, ARIC center, sex, education, physical activity, total caloric intake, smoking status, BMI, and waist-to-hip ratio.

  • §

    § Model 5: adjusted for age, race, ARIC center, education, sex, fasting insulin, fasting glucose, log triglycerides, HDL cholesterol, BMI, waist-to-hip ratio, systolic blood pressure, physical activity, total caloric intake, and smoking status.

  • P < 0.05.