Table 3

Association between serum hs-CRP concentration and development of diabetic nephropathy (shift from normoalbuminuria to microalbuminuria)

hs-CRP concentration quartiles
n = 486n = 252n = 359n = 293P value for trend
Median of hs-CRP (nmol/L)1.05.710.530.5
Interquartile range of hs-CRP (nmol/L)1.0–1.04.8–6.78.6–12.421.0–54.3
HR for development (95% CI)
 Crude modelRef1.50 (0.98–2.31)1.70 (1.35–2.14)1.62 (1.30–2.10)<0.001
 Age- and sex-adjusted modelRef1.49 (0.96–2.31)1.71 (1.38–2.12)1.61 (1.29–2.00)<0.001
 Multivariable-adjusted model*Ref1.31 (0.80–2.17)1.55 (1.16–2.08)1.57 (1.22–2.03)<0.001
  • *Adjusted for age, sex, BMI, exercise, smoking, systolic blood pressure, diastolic blood pressure, HDL, LDL, triglyceride, serum creatinine, eGFR, serum uric acid, ACE-I use, ARB use, statin use, HbA1c levels, past history of cardiovascular disease, past history of cancer, history of arthritis, NSAID use, and diabetic retinopathy.