Table 1—

Fasting and 60-min postprandial values in mixed meal tests using placebo or orlistat

ParameterPlacebo
Orlistat
FastingPostprandialFastingPostprandial
Serum glucose (mmol/l)6.2 ± 0.1610.7 ± 0.4*6.3 ± 0.199.57 ± 0.3*
Serum triglycerides (mmol/l)1.4 ± 0.081.78 ± 0.1*1.46 ± 0.11.6 ± 0.1*
Serum free fatty acids (mg/l)57 ± 7107 ± 8.8*58 ± 8104 ± 8*
Serum insulin (pmol/ml)80.3 ± 9.3423 ± 54.5*81.7 ± 9.3486 ± 46*
Serum C-peptide (pmol/ml)1.7 ± 0.123.2 ± 0.19*1.7 ± 0.14 ± 0.29*
Plasma GIP (pmol/l)1.6 ± 0.217.8 ± 1.4*2.3 ± 0.4116.1 ± 1.3*
Plasma GLP-1 (pmol/l)2.4 ± 0.53.49 ± 0.5*1.94 ± 0.34.8 ± 0.5*
  • Data are means ± SE. N = 29.

  • *

    * Significant difference in fasting versus postprandial values;

  • significant difference with orlistat versus with placebo.