Table 2—

Summary of electrophysiologic changes from baseline at 12 months in placebo patients

MeasureBaselineChange from baselineP (95% CI)*
Nerve conduction velocity (ms)
 Median forearm sensory471360
55.8 ± 4.5−0.05 ± 3.40.7703 (−0.04 to 0.03)
  HbA1c ≤8%275216
56.7 ± 4.4−0.13 ± 3.30.5582 (−0.57 to 0.31)
  HbA1c >8%, n170122
54.5 ± 4.4−0.06 ± 3.70.8553 (−0.73 to 0.6)
 Peroneal motor471359
40.2 ± 4.7−0.2 ± 2.20.0717 (−0.44 to 0.02)
  HbA1c ≤8%275216
40.8 ± 4.7−0.2 ± 2.20.1992 (−0.49 to 0.10)
  HbA1c >8%170121
39.2 ± 4.6−0.21 ± 2.10.2837 (−0.59 to 0.18)
 Sural sensory471357
41.6 ± 5−0.65 ± 3.70.0008 (−1.04 to −0.27)
  HbA1c ≤8%275216
42.3 ± 5−0.61 ± 3.70.0016 (−1.11 to −0.11)
  HbA1c >8%170119
40.6 ± 4.8−0.68 ± 3.40.0324 (−1.3 to −0.06)
Amplitude (μV)
 Median sensory471359
22.7 ± 12.4−0.80 ± 4.860.0021 (−1.3 to −0.29)
  HbA1c ≤8%275216
23.1 ± 12.2−0.59 ± 5.210.0983 (−1.29 to 0.11)
  HbA1c >8%170121
22 ± 12.8−1.03 ± 4.420.0116 (−1.82 to −0.23)
 Sural sensory470355
7.4 ± 4−0.30 ± 3.110.0686 (−0.63 to 0.02)
  HbA1c ≤8%275214
7.4 ± 3.9−0.16 ± 2.660.3904 (−0.52 to 0.20)
  HbA1c >8%170119
7.4 ± 4.3−0.44 ± 3.860.2194 (−1.14 to 0.26)
F-wave latency (ms)
 Median motor470355
29.1 ± 2.50.18 ± 0.920.002 (0.09 to 0.28)
  HbA1c ≤8%274214
28.9 ± 2.50.18 ± 0.890.0041 (0.06 to 0.3)
  HbA1c >8%170119
29.4 ± 4.50.15 ± 0.970.0887 (−0.02 to 0.33)
 Peroneal motor402276
54.6 ± 6.30.30 ± 3.080.1113 (−0.07 to 0.66)
  HbA1c ≤8%239170
54.1 ± 6.20.48 ± 3.280.0588 (−0.02 to 0.97)
  HbA1c >8%14392
55 ± 630.15 ± 2.140.6133 (−0.44 to 0.74)
  • Data are means ± SD.

  • *

    * None of the change from baseline comparisons between HbA1c strata are statistically different at P < 0.05.

  • No response values had a value imputed. See text for details.