Table 1—

Measures of glycemia and insulin secretion, lipids, and body weight before insulin therapy, directly after insulin therapy, and at 1-year follow-up

Before insulin treatmentAfter insulin treatment1 Year
Fasting serum glucose (mmol/l)13.3 ± 0.77.0 ± 0.4*6.7 ± 0.3
HbA1c (%)11.8 ± 0.36.6 ± 0.3
Fructosamine (μmol/l)428 ± 38286 ± 15*288 ± 11
AUCg (mmol · min)1,176 ± 661,184 ± 65916 ± 53
Fasting serum insulin (pmol/l)84.7 ± 10.897.6 ± 12.2108.3 ± 15.1
Fasting C-peptide (μg/l)1.04 ± 0.361.27 ± 0.29
AUCi (pmol · min)8,251 ± 1,88018,404 ± 4,04042,368 ± 8,517
Total cholesterol (mmol/l)6.16 ± 0.424.72 ± 0.28
Triglycerides (mmol/l)3.90 ± 0.722.08 ± 0.39
Free fatty acids (mmol/l)1.1 ± 0.100.76 ± 0.100.64 ± 0.08§
BMI (kg/m2)30.8 ± 1.930.9 ± 1.930.3 ± 1.8§
  • Data are means ± SE.

  • *

    * P < 0.01 significant difference of before versus after insulin treatment;

  • P < 0.01 significant difference of before versus after 1 year;

  • P < 0.01 significant difference of after insulin treatment versus 1 year; and

  • §

    § P < 0.05 significant difference after insulin treatment versus 1 year.