Table 2—

Clinical and biochemical characteristics at baseline or at the end of the initial insulin therapy of the group maintained on diet alone versus those requiring OHA or insulin on long-term follow-up

Diet onlyOHA/insulin
n79
BMI (kg/m2) before insulin therapy29.0 ± 2.132.2 ± 2.9
Waist-to-hip ratio before insulin therapy0.98 ± 0.021.01 ± 0.02
Fasting serum glucose before insulin therapy (mmol/l)13.2 ± 0.813.3 ± 1.1
Fasting serum glucose after insulin therapy (mmol/l)5.9 ± 0.37.7 ± 0.4*
HbA1c before insulin (%)12.3 ± 0.511.5 ± 0.5
Fasting insulin before insulin therapy (pmol/l)82.4 ± 16.586.7 ± 14.9
Fasting C-peptide before insulin therapy (μg/l)0.96 ± 0.311.10 ± 0.62
Free fatty acids before insulin therapy (mmol/l)0.94 ± 0.181.18 ± 0.11
AUCi before insulin therapy (pmol · min)7,937 ± 3,9838,498 ± 1,576
AUCi after insulin therapy (pmol · min)17,870 ± 6,17518,821 ± 5,661
Insulin dose required during intensive therapy (unit · kg−1 · day−1)0.37 ± 0.050.73 ± 0.07*
  • Data are means ± SE.

  • *

    * Significant difference of group maintained on diet only versus those requiring OHA or insulin (P < 0.01).