Table 2—

ORs for developing the metabolic syndrome or diabetes during the 11-year follow-up for men in the lowest fourth of concentrations of serum total and calculated free testosterone and SHBG at baseline in 702 men initially without the metabolic syndrome or diabetes

Total testosterone (<15.6 nmol/l)Calculated free testosterone (<253 pmol/l)SHBG (<28.3 nmol/l)
Metabolic syndrome at the 11-year follow-up (n/N = 147/702)
 Model 12.28 (1.54–3.38)1.71 (1.15–2.54)2.78 (1.88–4.12)
 Model 22.54 (1.69–3.81)1.91 (1.27–2.89)2.89 (1.93–4.33)
 Model 31.92 (1.24–1.96)1.58 (1.01–2.47)2.18 (1.42–3.36)
 Model 41.70 (1.07–2.70)1.57 (0.98–2.50)1.67 (1.05–2.65)
Diabetes at the 11-year follow up (n/N = 57/702)
 Model 12.33 (1.32–4.11)1.66 (0.93–2.96)4.34 (2.45–7.70)
 Model 22.37 (1.32–4.24)1.67 (0.91–3.05)4.33 (2.41–7.77)
 Model 31.95 (1.08–3.55)1.42 (0.77–2.62)3.60 (1.98–6.55)
 Model 41.97 (1.03–3.77)1.56 (0.80–3.06)2.74 (1.42–5.29)
  • Data are ORs (95% CI). Model 1: age-adjusted. Model 2: adjusted for age, presence of cardiovascular disease, smoking (none, 1–19 cigarettes/day, ≥20 cigarettes/day), alcohol consumption (none and four levels of alcohol intake), and socioeconomic status. Model 3: adjusted for the variables in model 2 and BMI. Model 4: adjusted for the variables in model 2 and age; waist (for the metabolic syndrome) or WHR (for diabetes); concentrations of insulin, glucose, and triglycerides; and systolic blood pressure and use of blood pressure medication.