Table 6—

Trials of ARIs

DrugResultsStatusRef.
AlrestatinMinor benefits (Sy)Withdrawn (toxicity)270
SorbinilBenefits (Sy, Ep, M)Withdrawn (toxicity)43
TolrestatMinor benefits (Sy, Ep)Withdrawn (toxicity)271
PonalrestatNo efficacyWithdrawn272
ZenarestatMinor benefits (Ep, M)Withdrawn (toxicity)53
EpalrestatMinor benefits (Sy, Ep)Marketed (Japan)269
FidarestatMinor benefits (Sy, Ep)Under investigation54
  • Ep, electrophysiology; M, motor; Sy, symptoms.