Table 8—

Oral symptomatic therapy of painful neuropathy

Drug classDrugDaily dose (mg)Side effectsRef.
TricyclicsAmitriptyline25–150++++280,281
Imipramine25–150++++280,281
SSRIsParoxitene40+++284
Citalopram40+++285
AnticonvulsantsGabapentin900–1,800++290,291
Lamotrigine200–400++292
CarbamazepineUp to 800+++289
Antiarrhythmics*MexiliteneUp to 450+++293,294
OpioidsTramadol50–400+++295,296
Oxycodone CR10–60++++297,298
  • All medications in the table have demonstrated efficacy in randomized controlled studies.

  • *

    * Mexilitene should be used with caution and with regular EKG monitoring;

  • oxycodone CR may be useful as an add-on therapy in severe symptomatic neuropathy.