Table 2—

Cardiovascular events in relation to insulin resistance with lower and higher risk levels of HDL cholesterol and triglycerides

No insulin resistanceInsulin resistanceRelative difference in events [% (95% CI)]P
HDL cholesterol
 <31.5 mg/dl79/344 (23.0)75/231 (32.5)29 (7–46)0.012
 ≥31.5 mg/dl76/404 (18.8)50/164 (30.5)38 (16–55)0.002
 <152 mg/dl81/418 (19.4)49/143 (34.3)43 (24–58)0.0003
 ≥152 mg/dl74/330 (22.4)76/252 (30.2)25 (2–43)0.035
  • Data are event/total n (% events) unless otherwise indicated. Reproduced with permission from Robins et al. (91). Values are shown for the entire placebo group with plasma insulin, glucose, and lipid values measured at baseline (n = 1,143). Subjects with diabetes who were being treated with insulin were excluded from the analyses. HDL cholesterol and triglycerides were separated into higher and lower cardiovascular risk categories at the median value of HDL cholesterol of 31.5 mg/dl and median value of triglycerides of 152 mg/dl. Insulin resistance was defined by the highest tertile of homeostasis model assessment of insulin resistance values. The relative difference in cardiovascular events between groups with and without insulin resistance and between lower and higher levels of HDL cholesterol and triglycerides was calculated by χ2.