Table 2—

Clinical parameters on INS alone, after 4 months of combination therapy (INS + MET or INS + TGZ), followed by 4 months of triple therapy

INS + MET, add TGZ
INS + TGZ, add MET
INSINS + MET (week 16)INS + MET add TGZ (week 32)INSINS + TGZ (week 16)INS + TGZ add MET (week 32)
Weight (kg)112.6 ± 26.4112.4 ± 25.2112.2 ± 23.2100.3 ± 13.8104.7 ± 12.8*104.0 ± 12.9
BMI (kg/m2)38.5 ± 7.838.4 ± 7.338.4 ± 6.936.4 ± 5.738.0 ± 5.5*37.7 ± 5.3
Insulin dose (units/day)71.6 ± 49.768.4 ± 47.151.1 ± 24.9§98.3 ± 36.784.2 ± 28.0*70.5 ± 22.3
FPG (mg/dl)#183.1 ± 54.6138.8 ± 38.7*121.1 ± 22.6187.1 ± 38.5137.0 ± 41.5*126.4 ± 22.9
HbA1c (%)8.5 ± 1.37.0 ± 0.8*6.1 ± 0.48.4 ± 1.06.2 ± 0.8*5.8 ± 0.6
Total cholesterol (mg/dl)177.2 ± 35.7175.4 ± 35.1186.6 ± 40.0187.6 ± 47.8212.9 ± 45.0212.3 ± 52.3
HDL cholesterol (mg/dl)30.2 ± 4.331.3 ± 7.735.0 ± 8.130.1 ± 10.635.1 ± 9.135.7 ± 6.7*
LDL cholesterol (mg/dl)103.0 ± 38.4103.0 ± 34.7110.9 ± 36.8103.4 ± 29.2128.7 ± 26.8*125.3 ± 35.4
Triglycerides (mg/dl)205.7 ± 149.2200.0 ± 133.9160.3 ± 89.1206.7 ± 141.6165.3 ± 65.5178.0 ± 135.9
VLDL triglycerides (mg/dl)150.1 ± 136.2162.8 ± 137.3119.8 ± 87.4164.7 ± 141.9133.5 ± 69.3142.1 ± 137.9
  • Data are means ± SD.

  • *

    * P < 0.05 vs. baseline;

  • P < 0.05 vs. week 16;

  • P < 0.05 vs. INS + MET;

  • §

    § P < 0.05 vs. INS + MET, add TGZ;

  • #

    # conversion factor for SI units in mmol/l is 0.0555;

  • n = 13 for lipid parameters for INS + MET; n = 12 for INS + TGZ.