Table 3—

Insulin and C-peptide AUC for different time intervals and metabolic parameters during FSIGT without (control) and with alcohol

ParameterUnitControl subjects
Type 2 diabetic subjects
P value between control studiesP value between alcohol studies
Control studyAlcohol studyPControl studyAlcohol studyP
Total insulin AUCpmol/l in 180 min44.1 ± 5.933.4 ± 6.5NS57.1 ± 8.848.6 ± 9.1NSNSNS
Total C-peptide AUCnmol/l in 180 min149 ± 19175 ± 29NS130 ± 23144 ± 24NSNSNS
Suprabasal insulin AUC (early phase [0–15])pmol/l in 15 min0.6 ± 0.120.72 ± 0.24NS0.24 ± 0.060.30 ± 0.12NS0.0030.009
Suprabasal C-peptide AUC (early phase [0–15])nmol/l in 15 min13.9 ± 2.616.6 ± 4.3NS9.3 ± 1.38.9 ± 1.3NS0.00060.004
Total C-peptide AUC (second phase [20–180])nmol/l in 180 min120 ± 16141 ± 23NS115 ± 21129 ± 23NSNSNS
Glucose effectivenessmin−10.027 ± 0.0020.025 ± 0.003NS0.019 ± 0.0030.023 ± 0.003NSNSNS
Si10−4 min−1 · μU−1 · ml2.88 ± 0.764.52 ± 0.950.0280.93 ± 0.262.47 ± 0.570.0090.029NS
AIRgpmol/l232 ± 62278 ± 24NS16 ± 723 ± 8NS0.0030.009
Disposition index10−4 min−183 ± 19157 ± 380.0253 ± 210 ± 40.0220.0080.007
  • Data are means ± SEM unless otherwise indicated. Time intervals (minutes) during which the variables are calculated are reported in brackets.