Table 2—

Body weight, body composition, and glycemic control parameters before and after 8 weeks’ intervention

VariableLiraglutidePlaceboP
n2112
Weight (kg)
    Before106.9 ± 2.998.0 ± 3.8
    After104.8 ± 3.096.0 ± 4.0
    Change−0.7 (−1.6 to 0.3)−0.9 (−2.2 to 0.4)0.756
Waist circumference (cm)
    Before114.6 ± 2.0108.6 ± 2.0
    After114.0 ± 2.0107.8 ± 2.4
    Change−0.5 (−1.6 to 0.6)−1.1 (−2.6 to 0.4)0.505
Fat mass (kg)
    Before41.4 ± 2.339.3 ± 1.9
    After39.8 ± 2.138.6 ± 2.0
    Change−1.0 (−1.8 to −0.3)−0.7 (−1.7 to 0.4)0.590
Lean mass (kg)
    Before59.6 ± 2.549.7 ± 1.9
    After60.2 ± 2.649.5 ± 2.1
    Change0.7 (−0.1 to 1.6)0.2 (−1.4 to 1.1)0.259
Fat mass (%)
    Before39.5 ± 1.842.7 ± 1.2
    After38.5 ± 1.742.4 ± 1.0
    Change−1.0 (−1.6 to −0.4)−0.1 (−0.9 to 0.7)0.088
Lean mass (%)
    Before57.0 ± 1.854.1 ± 1.2
    After58.1 ± 1.654.5 ± 1.1
    Change1.0 (0.5 to 1.6)0.2 (−0.6 to 1.0)0.118
Fasting serum glucose (mmol/l)
    Before10.7 ± 0.510.4 ± 0.8
    After8.8 ± 0.510.7 ± 1.0
    Change−1.9 (−2.7 to −1.1)0.3 (−0.8 to 1.3)0.002
HbA1c (%)
    Before7.37 ± 0.217.68 ± 0.47
    After7.07 ± 0.248.10 ± 0.47
    Change−0.33 (−0.75 to 0.09)0.47 (−0.09 to 1.03)0.028
Fructosamine (μmol/l)
    Before298.5 ± 10.9293.8 ± 18.6
    After272.8 ± 9.0313.4 ± 16.1
    Change−25.0 (−41.2 to −8.9)18.3 (−3.1 to 39.6)0.003
Insulin (pmol/l)
    Before124.8 ± 14.2147.2 ± 53.4
    After118.7 ± 16.7122.8 ± 48.7
    Change−7.8 (−38.1 to 22.5)−21.5 (−61.6 to 18.5)0.581
C-peptide (nmol/l)
    Before1.48 ± 0.131.64 ± 0.39
    After1.52 ± 0.131.53 ± 0.35
    Change0.02 (−0.22 to 0.26)−0.09 (−0.41 to 0.23)0.592
  • Data are means ± SE or mean change values (95% CI). All change values are adjusted for differences in baseline values between groups.