Table 3—

Effects of therapy on markers of oxidative stress and metabolic indexes

Baseline
After 4 weeks of therapy
QuinaprilPlaceboPQuinaprilPlaceboP
n20202020
8-isoprostane (pg/ml)54.4 ± 1.453.2 ± 1.2NS46.7 ± 252.7 ± 0.90.001
E-SOD activity (units/g Hb)609.3 ± 9.8612.7 ± 9NS826.3 ± 17.1612.3 ± 6.90.001
Lag time to LDL oxidation (min)60.5 ± 10.161.0 ± 8.7NS89.2 ± 9.260.1 ± 12.30.001
LDL cholesterol (mg/dl)124.7 ± 21.4130 ± 16.8NS122.9 ± 19.2133.1 ± 17.8NS
Triglycerides (mg/dl)238 ± 36219 ± 30NS234 ± 31227 ± 24NS
Fasting glucose (mg/dl)113 ± 15111 ± 19NS116 ± 17115 ± 13NS
HbA1c (%)5.8 ± 0.75.6 ± 0.8NS5.6 ± 0.65.7 ± 0.7NS
  • Data are means ± SE.