Table 1—

Features to differentiate type 1 and 2 diabetes in young people

Type 1 diabetesType 2 diabetes
OnsetAcute—symptomaticSlow—often asymptomatic
Clinical picture• Weight loss• Obese
• Polyuria• Strong family history type 2 diabetes
• Polydipsia• Ethnicity—high-prevalence populations
• Acanthosis nigricans
KetosisAlmost always presentUsually absent
Insulin• C-peptide negative• C-peptide positive
Antibodies• ICA positive• ICA negative
• Anti-GAD positive• Anti-GAD negative
• ICA 512 positive• ICA 512 negative
TherapyInsulin invariablyOral hypoglycemic agents
Associated autoimmune diseasesYesNo